Raphael Stoll Selected Research

Neoplasms (Cancer)

1/2021	Sequence-Selective Covalent CaaX-Box Receptors Prevent Farnesylation of Oncogenic Ras Proteins and Impact MAPK/PI3 K Signaling.
12/2019	Phosphorylation orchestrates the structural ensemble of the intrinsically disordered protein HMGA1a and modulates its DNA binding to the NFκB promoter.
4/2018	Structural studies on radiopharmaceutical DOTA-minigastrin analogue (CP04) complexes and their interaction with CCK2 receptor.
4/2018	Allosteric Activation of GDP-Bound Ras Isoforms by Bisphenol Derivative Plasticisers.
1/2017	The small GTPases Ras and Rheb studied by multidimensional NMR spectroscopy: structure and function.
1/2017	Human melanoma inhibitory protein binds to the FN12-14 Hep II domain of fibronectin.
9/2016	Design, Synthesis, and Cytotoxicity of 5-Fluoro-2-methyl-6-(4-aryl-piperazin-1-yl) Benzoxazoles.
9/2014	Identification of compounds that selectively target highly chemotherapy refractory neuroblastoma cancer stem cells.
8/2014	Sequence-selective molecular recognition of the C-terminal CaaX-boxes of Rheb and related Ras-proteins by synthetic receptors.
12/2013	Bisphenol A binds to Ras proteins and competes with guanine nucleotide exchange: implications for GTPase-selective antagonists.

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Raphael Stoll Research Topics

Disease

13	Neoplasms (Cancer) 01/2021 - 06/2012
8	Melanoma (Melanoma, Malignant) 10/2018 - 03/2003
5	Neoplasm Metastasis (Metastasis) 01/2017 - 11/2003
4	Tuberous Sclerosis (Bourneville's Disease) 01/2017 - 07/2007
2	Neuroblastoma 10/2018 - 09/2014
1	Thyroid Neoplasms (Thyroid Cancer) 04/2018
1	Brain Diseases (Brain Disorder) 01/2017
1	Carcinoma (Carcinomatosis) 09/2016
1	Lung Neoplasms (Lung Cancer) 09/2016
1	Multiple Sclerosis 07/2015
1	Autoimmune Diseases (Autoimmune Disease) 07/2015
1	Diabetes Mellitus 07/2015
1	Schizophrenia (Dementia Praecox) 10/2014
1	Colorectal Neoplasms (Colorectal Cancer) 08/2014
1	Skin Neoplasms (Skin Cancer) 01/2012
1	Wilms Tumor (Wilm's Tumor) 10/2007

Drug/Important Bio-Agent (IBA)

12	Proteins (Proteins, Gene)FDA Link 12/2019 - 03/2003
5	Fibronectins (Fibronectin)IBA 10/2018 - 11/2003
4	GTP Phosphohydrolases (GTPases)IBA 01/2017 - 07/2007
3	Pharmaceutical PreparationsIBA 01/2017 - 09/2014
2	ras ProteinsIBA 01/2021 - 08/2014
2	Heparin (Liquaemin)FDA LinkGeneric 10/2018 - 01/2017
2	1,7- dioxa- 2,6- diaza- 4,7a- dithia- 3H,5H- benzo(cd)pentaleneIBA 10/2018 - 01/2017
2	Guanosine Triphosphate (GTP)IBA 01/2017 - 05/2013
2	Propolis (Bee Bread)IBA 09/2014 - 01/2013
2	Phosphotransferases (Kinase)IBA 05/2013 - 07/2007
2	Peptides (Polypeptides)IBA 06/2012 - 11/2003
2	Monomeric GTP-Binding ProteinsIBA 07/2007 - 07/2007
1	Nuclear Proteins (Protein, Nuclear)IBA 12/2019
1	4,4- dimethyl- 1,7- dioxa- 2,6- diaza- 7a- thia- 3H,5H- benzo(cd)pentaleneIBA 10/2018
1	Radioisotopes (Radionuclides)IBA 04/2018
1	Cholecystokinin Receptors (Cholecystokinin Receptor)IBA 04/2018
1	Protein Isoforms (Isoforms)IBA 04/2018
1	GTPase-Activating Proteins (GTPase-Activating Protein)IBA 01/2017
1	CollagenIBA 01/2017
1	Guanosine Diphosphate (GDP)IBA 01/2017
1	BenzoxazolesIBA 09/2016
1	Potassium Channels (Potassium Channel)IBA 07/2015
1	Glutamic Acid (Glutamate)FDA Link 10/2014
1	1-Phosphatidylinositol 4-Kinase (1 Phosphatidylinositol 4 Kinase)IBA 10/2014
1	Cytostatic AgentsIBA 09/2014
1	4,4'-dihydroxybiphenylIBA 12/2013
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 05/2013
1	FlavonoidsIBA 01/2013
1	Biological ProductsIBA 06/2012
1	3-Tyr-octreotideIBA 06/2012
1	Leucine EnkephalinIBA 06/2012
1	WT1 ProteinsIBA 10/2007
1	DNA (Deoxyribonucleic Acid)IBA 10/2007
1	Extracellular Matrix ProteinsIBA 12/2006

Therapy/Procedure

4	Therapeutics 04/2018 - 01/2012
1	Precision Medicine 04/2018
1	Drug Therapy (Chemotherapy) 09/2014